(2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide
Uses- Product Name
- (2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide
- CAS No.
- 2101517-69-3
- Chemical Name
- (2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide
- Synonyms
- BL 918 NEW;BL-918 (BL918);(2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide;Benzeneacetamide, α-[[[[3,5-bis(trifluoromethyl)phenyl]amino]thioxomethyl]amino]-N-(2,4-difluorophenyl)-, (αR)-;inhibit,disease,BL-918,cytoprotective,BL 918,BL918,Autophagy,kinase,autophagic,Unc-51 like kinase,Orally,Parkinson’s,ULK,Inhibitor
- CBNumber
- CB54747731
- Molecular Formula
- C23H15F8N3OS
- Formula Weight
- 533.4369256
- MOL File
- 2101517-69-3.mol
(2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide Property
- Density
- 1.508±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: ≥ 250 mg/mL (468.66 mM)
- form
- A solid
- pka
- 11.13±0.70(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B595838
- Product name
- BL918
- Packaging
- 5mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- KIN0008598
- Product name
- BL-918
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $458.3
- Updated
- 2021/12/16
- Product number
- BB165666
- Product name
- BL 918 NEW
- Packaging
- 50mg
- Price
- $542.5
- Updated
- 2021/12/16
- Product number
- 1916EP
- Product name
- (2R)-2-[[3,5-Bis(trifluoromethyl)phenyl]carbamothioylamino]-N-(2,4-difluorophenyl)-2-phenylacetamide
- Packaging
- 50mg
- Price
- $782
- Updated
- 2021/12/16
- Product number
- BB165666
- Product name
- BL 918 NEW
- Packaging
- 10mg
- Price
- $155
- Updated
- 2021/12/16
(2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide Chemical Properties,Usage,Production
Uses
BL 918 is a potent small-molecule activator of UNC-51-like kinase 1 (ULK1), a serine-threonine kinase involved in autophagy. Promotes cytoprotective autophagy in MPP+-treated SH-SY5Y cells, via the ULK complex. Improves motor dysfunction and reduces loss of dopaminergic neurons, mediated by MPTP, in in vivo models of Parkinson’s disease.
Uses
BL 918 is a potent small-molecule activator of UNC-51-like kinase 1 (ULK1), a serine-threonine kinase involved in autophagy. Promotes cytoprotective autophagy in MPP+-treated SH-SY5Y cells, via the ULK complex. Improves motor dysfunction and reduces loss of dopaminergic neurons, mediated by MPTP, in in vivo models of Parkinson’s disease.
(2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide Preparation Products And Raw materials
Raw materials
Preparation Products
(2R)-2-({[3,5-bis(trifluoromethyl)phenyl]carbamothioyl}amino)-N-(2,4-difluorophenyl)-2-phenylacetamide Suppliers
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